Factorization in integrable systems with impurity

This article is based on recent works done in collaboration with M. Mintchev, E. Ragoucy and P. Sorba. It aims at presenting the latest developments in the subject of factorization for integrable field theories with a reflecting and transmitting impurity.Comment: 7 pages; contribution to the XIVth International Colloquium on Integrable systems, Prague, June 200

Calculating the local-type fNL for slow-roll inflation with a non-vacuum initial state

Single-field slow-roll inflation with a non-vacuum initial state has an enhanced bispectrum in the local limit. We numerically calculate the local-type fNL signal in the CMB that would be measured for such models (including the full transfer function and 2D projection). The nature of the result depends on several parameters, including the occupation number N_k, the phase angle \theta_k between the Bogoliubov parameters, and the slow-roll parameter \epsilon. In the most conservative case, where one takes \theta_k \approx \eta_0 k (justified by physical reasons discussed within) and \epsilon\lesssim 0.01, we find that 0 < fNL < 1.52 (\epsilon/0.01), which is likely too small to be detected in the CMB. However, if one is willing to allow a constant value for the phase angle \theta_k and N_k=O(1), fNL can be much larger and/or negative (depending on the choice of \theta_k), e.g. fNL \approx 28 (\epsilon/0.01) or -6.4 (\epsilon/0.01); depending on \epsilon, these scenarios could be detected by Planck or a future satellite. While we show that these results are not actually a violation of the single-field consistency relation, they do produce a value for fNL that is considerably larger than that usually predicted from single-field inflation.Comment: 8 pages, 1 figure. v2: Version accepted for publication in PRD. Added greatly expanded discussion of the phase angle \theta_k; this allows the possibility of enhanced fNL, as mentioned in abstract. More explicit comparisons with earlier wor

Quality changes during postharvest life in white fleshed peach (Prunus Persica L. Batsch) fruits: Preliminary observations

Sicilian white flesh peach fruits ecotypes are characterized by a persistent aroma and excellent flavor that is highly appreciated by consumers. Nevertheless, they reach only regional markets, because of fruit sensitivity to decay and the poor information about their postharvest physiology and shelf-life. In this trial, we studied quality changes during postharvest life of non-melting white-flesh peach ecotypes \u2018Tudia\u2019, \u2018Bella di Bivona\u2019 and the cultivar \u2018Daniela\u2019. Fruits were collected at commercial ripening: a first group was submitted to analytical evaluations and another one was stored (2\ub0C, 90% RH) for 32 days. During this storage period, fruits were submitted to four shelf-life periods at ambient temperature (22\ub0C) for 6 days and analyzed every 3th and 6th day. In the period of shelf-life, during storage of fruit at 2\ub0C, we ascertained that Bella di Bivona and Daniela have a shelf-life of 12-14 days while \u2018Tudia\u2019 could reach up to 25-32 days. Flesh firmness and chilling injuries trends, during shelf-life, allowed to discover \u2018Tudia\u2019 as the variety which presents the best performance after storage at low temperatures for long periods

Advanced radar-interpretation of InSAR time series for mapping and characterization of geological processes

We present a new post-processing methodology for the analysis of InSAR (Synthetic Aperture Radar Interferometry) multi-temporal measures, based on the temporal under-sampling of displacement time series, the identification of potential changes occurring during the monitoring period and, eventually, the classification of different deformation behaviours. The potentials of this approach for the analysis of geological processes were tested on the case study of Naro (Italy), specifically selected due to its geological setting and related ground instability of unknown causes that occurred in February 2005. The time series analysis of past (ERS1/2 descending data; 1992–2000) and current (RADARSAT-1 ascending data; 2003–2007) ground movements highlighted significant displacement rates (up to 6 mm yr&lt;sup&gt;−1&lt;/sup&gt;) in 2003–2007, followed by a post-event stabilization. The deformational behaviours of instable areas involved in the 2005 event were also detected, clarifying typology and kinematics of ground instability. The urban sectors affected and unaffected by the event were finally mapped, consequently re-defining and enlarging the influenced area previously detected by field observations. Through the integration of InSAR data and conventional field surveys (i.e. geological, geomorphologic and geostructural campaigns), the causes of instability were finally attributed to tectonics

OPA1-related auditory neuropathy: site of lesion and outcome of cochlear implantation.

Hearing impairment is the second most prevalent clinical feature after optic atrophy in Dominant Optic Atrophy associated with mutations in the OPA1 gene. In this study we characterized the hearing dysfunction in OPA1-linked disorders and provided effective rehabilitative options to improve speech perception. We studied two groups of OPA1 subjects, one comprising 11 patients (7 males; age range 13-79 years) carrying OPA1 mutations inducing haploinsufficiency, the other, 10 subjects (3 males; age range 5-58 years) carrying OPA1 missense mutations. Both groups underwent audiometric assessment with pure tone and speech perception evaluation, and otoacoustic emissions and auditory brainstem response recording. Cochlear potentials were recorded through transtympanic electrocochleography from the group of patients harboring OPA1 missense mutations and were compared to recordings obtained from 20 normally-hearing controls and from 19 subjects with cochlear hearing loss. Eight patients carrying OPA1 missense mutations underwent cochlear implantation. Speech perception measures and electrically-evoked auditory nerve and brainstem responses were obtained after one year of cochlear implant use. Nine out of 11 patients carrying OPA1 mutations inducing haploinsufficiency had normal hearing function. In contrast, all but one subject harboring OPA1 missense mutations displayed impaired speech perception, abnormal brainstem responses and presence of otoacoustic emissions consistent with auditory neuropathy. In electrocochleography recordings, cochlear microphonic had enhanced amplitudes while summating potential showed normal latency and peak amplitude consistent with preservation of both outer and inner hair cell activities. After cancelling the cochlear microphonic, the synchronized neural response seen in both normally-hearing controls and subjects with cochlear hearing loss was replaced by a prolonged, low-amplitude negative potential that decreased in both amplitude and duration during rapid stimulation consistent with neural generation. The use of cochlear implant improved speech perception in all but one patient. Brainstem potentials were recorded in response to electrical stimulation in five subjects out of six, whereas no compound action potential was evoked from the auditory nerve through the cochlear implant. These findings indicate that underlying the hearing impairment in patients carrying OPA1 missense mutations is a disordered synchrony in auditory nerve fiber activity resulting from neural degeneration affecting the terminal dendrites. Cochlear implantation improves speech perception and synchronous activation of auditory pathways by by-passing the site of lesion

Food quality, sensory attributes and nutraceutical value of fresh “Osteen” mango fruit grown under mediterranean subtropical climate compared to imported fruit

Mango is a fruit with a very short shelf-life due to its rapid ripeness after harvest; it is high in B vitamins, contains some amounts of magnesium, calcium, zinc, and selenium and it is rich in soluble and insoluble fibers. In order to reach the European markets at proper marketable maturity, fruit from tropical countries are harvested at early maturity stage. Although this harvesting practice improves mango postharvest life, fruit reach the market with very low quality, especially in terms of taste. The present study was conducted to evaluate food quality, sensory attributes and nutraceutical value of “Osteen” fresh Mediterranean Italian mango fruit, and imported ones coming from tropical countries. Mango fruit imported from abroad were collected from 5 large-scale organized markets; fresh Italian mango fruit were harvested from a commercial orchard, at green-and mature-ripe stage. Imported and fresh Italian mango fruit were analyzed in terms of firmness, total soluble solids content, titratable acidity, flesh disorders, nutraceutical value, and sensory attributes. Mediterranean Italian mango fruit showed the best quality performances in terms of nutraceutical value and quality attributes. Sensorial analysis confirmed this behavior, these quality attributes, were perceived by the trained panel, that preferred fresh Mediterranean mango fruit

A rapid and simple uhplc-ms/ms method for quantification of plasma globotriaosylsphingosine (Lyso-gb3)

Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by α-galactosidase A gene (GLA) mutations, resulting in loss of activity of the lysosomal hydrolase, α-galactosidase A (α-Gal A). As a result, the main glycosphingolipid substrates, globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3), accumulate in plasma, urine, and tissues. Here, we propose a simple, fast, and sensitive method for plasma quantification of lyso-Gb3, the most promising secondary screening target for FD. Assisted protein precipitation with methanol using Phree cartridges was performed as sample pre-treatment and plasma concentrations were measured using UHPLC-MS/MS operating in MRM positive electrospray ionization. Method validation provided ex-cellent results for the whole calibration range (0.25–100 ng/mL). Intra-assay and inter-assay accuracy and precision (CV%) were calculated as &lt;10%. The method was successfully applied to 55 plasma samples obtained from 34 patients with FD, 5 individuals carrying non-relevant polymorphisms of the GLA gene, and 16 healthy controls. Plasma lyso-Gb3 concentrations were larger in both male and female FD groups compared to healthy subjects (p &lt; 0.001). Normal levels of plasma lyso-Gb3 were observed for patients carrying non-relevant mutations of the GLA gene compared to the control group (p = 0.141). Dropping the lower limit of quantification (LLOQ) to 0.25 ng/mL allowed us to set the optimal plasma lyso-Gb3 cut-off value between FD patients and healthy controls at 0.6 ng/mL, with a sensitivity of 97.1%, specificity of 100%, and accuracy of 0.998 expressed by the area under the ROC curve (C.I. 0.992 to 1.000, p-value &lt; 0.001). Based on the results obtained, this method can be a reliable tool for early phenotypic assignment, assessing diagnoses in patients with borderline GalA activity, and confirming non-relevant mutations of the GLA gene

Mediterranean diet, physical activity and gut microbiome composition: A cross-sectional study among healthy young italian adults

Background. This cross-sectional study aimed to explore the microbial composition of the gut and its possible association with the Mediterranean diet (MD) after adjusting for demographic and anthropometric characteristics in a sample of healthy young Italian adults. Methods. Gut microbiota, demographic information, and data on adherence to MD and physical activity (PA) habits were collected in a sample of 140 university students (48.6% males, mean age 22.5 ± 2.9) with a mean body mass index (BMI) of 22.4 ± 2.8 kg/m2 (15.2–33.8) and a mean PA level of 3006.2 ± 2973.6 metabolic equivalent (MET)-minutes/week (148–21,090). Results. A high prevalence of Firmicutes and Bacteroidetes was found in all the fecal samples. Significant dissimilarities in the microbiota composition were found on the basis of MD adherence and PA levels (p = 0.001). At the genus level, Streptococcus and Dorea were highly abundant in overweight/obese individuals, Ruminococcus and Oscillospira in participants with lower adherence to MD, and Lachnobacterium in subjects with low levels of PA (p = 0.001). A significantly higher abundance of Paraprevotella was shown by individuals with lower BMI, lower MD adherence, and lower PA levels (p = 0.001). Conclusions. This study contributes to the characterization of the gut microbiome of healthy humans. The findings suggest the role of diet and PA in determining gut microbiota variability